Inositol trisphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Inositol trisphosphate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THNSL1, CYHR1, and ZCCHC13, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, THNSL1 grouped by Inositol trisphosphate metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	THNSL1 →	+0.262	+0.208	.006	.004	3	1
SKIN	CYHR1 →	+0.245	+0.158	.001	.007	3	1
SKIN	ZCCHC13 →	+0.118	+0.184	.005	.008	3	1
SKIN	RING1 →	+0.290	+0.233	.008	.004	3	1
SKIN	RUNX3 →	+0.253	+0.171	.004	.003	3	1
SKIN	DDX47 →	-0.312	-0.164	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THNSL1 by Inositol trisphosphate metabolic process activity — SKIN

Explore this box plot interactively →