Inositol trisphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Inositol trisphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF141, CD81, and ITFG2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inositol trisphosphate metabolic process activity versus RNF141 in SKIN (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RNF141 →	+0.457	+0.166	.005	.002	3	1
SKIN	CD81 →	+0.713	+0.183	.001	<.001	3	1
SKIN	ITFG2 →	+0.543	+0.188	.005	.005	3	1
SKIN	RSPH4A →	+0.164	+0.173	<.001	.005	3	1
SKIN	STAT1 →	+1.114	+0.212	<.001	.004	3	1
SKIN	WIPF1 →	+1.365	+0.165	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032957 vs RNF141 — SKIN

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