Secretion by tissue

Across TCGA patient cohorts, RNA activity of the Secretion by tissue pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PI4K2A, ITGA3, and BRMS1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Secretion by tissue activity versus PI4K2A in LUAD (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PI4K2A →	+0.309	+0.211	<.001	<.001	3	4
LUAD	ITGA3 →	+0.709	+0.208	.003	.002	3	4
COAD	BRMS1L →	-0.420	-0.196	.001	.001	3	4
CCRCC	OAZ1 →	+0.292	+0.199	<.001	.004	3	3
CCRCC	LHFPL2 →	+0.646	+0.193	<.001	.001	3	3
LUAD	METRNL →	+0.531	+0.232	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032941 vs PI4K2A — LUAD

Explore this scatter interactively →