Secretion by tissue

Across TCGA cell cohorts, RNA activity of the Secretion by tissue pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMEPA1, DCAF1, and CNOT10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PMEPA1 grouped by Secretion by tissue-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PMEPA1 →	+3.317	+0.351	<.001	<.001	3	5
LUNG_SCLC	DCAF1 →	-0.554	-0.294	.008	.001	2	5
BLOOD_Leukemia	CNOT10 →	-0.711	-0.300	<.001	<.001	3	4
BLOOD_Myeloma	PEA15 →	-1.172	-0.386	.003	.005	2	5
BONE	KTN1 →	+1.073	+0.257	.004	.006	2	4
OVARY	GREM1 →	+2.262	+0.167	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PMEPA1 by Secretion by tissue activity — OVARY

Explore this box plot interactively →