Secretion by tissue

Across TCGA cell cohorts, RNA activity of the Secretion by tissue pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBBP1A, P2RX1, and SPR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYBBP1A grouped by Secretion by tissue-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MYBBP1A →	+0.505	+0.222	.003	.001	3	5
BREAST	P2RX1 →	-0.107	-0.186	.007	.002	3	4
BREAST	SPR →	+0.276	+0.210	.007	.001	3	4
PANCREAS	NT5E →	-0.193	-0.231	.002	.007	3	4
BREAST	RING1 →	+0.355	+0.266	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	OTOF →	-0.390	-0.168	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYBBP1A by Secretion by tissue activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →