Secretion by tissue

Across TCGA cell cohorts, RNA activity of the Secretion by tissue pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNA2, CCR3, and IKBKG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCNA2 grouped by Secretion by tissue-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCNA2 →	+0.316	+0.222	.006	.002	3	4
BREAST	CCR3 →	+0.222	+0.352	.002	<.001	3	4
BREAST	IKBKG →	-0.120	-0.250	.004	.002	3	4
LARGE_INTESTINE	ITGA7 →	+0.092	+0.186	.005	.004	3	3
BREAST	RALB →	+0.214	+0.300	<.001	<.001	3	3
LUNG_SCLC	UBE2E4P →	-0.201	-0.290	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCNA2 by Secretion by tissue activity — LARGE_INTESTINE

Explore this box plot interactively →