Secretion by tissue

Across TCGA cell cohorts, RNA activity of the Secretion by tissue pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP3, AGR2, and ANKRD22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Secretion by tissue activity versus TJP3 in BREAST (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TJP3 →	+2.644	+0.371	<.001	<.001	3	5
BREAST	AGR2 →	+5.101	+0.251	<.001	<.001	3	5
BREAST	ANKRD22 →	+2.097	+0.360	.001	.001	3	5
LUNG_NSCLC_LUAD	HSH2D →	+1.634	+0.249	<.001	<.001	3	5
URINARY_TRACT	PDIA6 →	-0.709	-0.458	<.001	<.001	3	5
LUNG_NSCLC_LUAD	UBASH3B →	-1.686	-0.229	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032941 vs TJP3 — BREAST

Explore this scatter interactively →