Positive regulation of superoxide anion generation

Across TCGA patient cohorts, RNA activity of the Positive regulation of superoxide anion generation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL10RA, HCLS1, and NCF1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of superoxide anion generation activity versus IL10RA in GBM (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL10RA →	+1.175	+0.320	<.001	<.001	3	7
GBM	HCLS1 →	+1.079	+0.375	<.001	<.001	3	7
GBM	NCF1B →	+0.708	+0.380	<.001	<.001	3	7
GBM	FCGR2B →	+0.956	+0.264	.001	.002	3	7
GBM	FGR →	+0.744	+0.282	<.001	<.001	3	7
GBM	CSF2RB →	+0.780	+0.295	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032930 vs IL10RA — GBM

Explore this scatter interactively →