Positive regulation of superoxide anion generation

Across TCGA cell cohorts, RNA activity of the Positive regulation of superoxide anion generation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SACS, C19orf48, and C1QL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of superoxide anion generation activity versus SACS in BREAST (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SACS →	+1.821	+0.231	<.001	.004	3	6
BREAST	C19orf48 →	-0.804	-0.233	.005	.009	3	6
URINARY_TRACT	C1QL1 →	+1.762	+0.262	.008	.002	3	5
BREAST	DHRS13 →	-1.030	-0.194	.004	.005	3	5
LUNG_NSCLC_LUAD	PKP2 →	-1.291	-0.197	.008	.006	3	5
OVARY	CAV1 →	+3.694	+0.196	.003	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032930 vs SACS — BREAST

Explore this scatter interactively →