Regulation of superoxide anion generation

Across TCGA cell cohorts, RNA activity of the Regulation of superoxide anion generation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOLC1, HEATR3, and FANCA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOLC1 grouped by Regulation of superoxide anion generation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NOLC1 →	+0.977	+0.887	.001	.006	3	5
BREAST	HEATR3 →	+0.683	+0.967	.001	<.001	3	5
BREAST	FANCA →	+0.908	+0.923	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PROSER1 →	+0.595	+0.900	.002	.005	3	4
SKIN	ZNF341 →	+0.236	+0.897	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	CDCA5 →	+1.643	+0.869	.006	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOLC1 by Regulation of superoxide anion generation activity — UPPER_AERODIGESTIVE_TRACT

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