Regulation of superoxide anion generation

Across TCGA cell cohorts, RNA activity of the Regulation of superoxide anion generation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C19orf48, GNAI2, and CAV1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of superoxide anion generation activity versus C19orf48 in BREAST (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	C19orf48 →	-0.683	-0.251	.007	.001	3	6
OVARY	GNAI2 →	+0.738	+0.113	.006	.009	3	5
OVARY	CAV1 →	+3.767	+0.196	.002	.001	2	6
BREAST	MAP1B →	+2.667	+0.293	<.001	<.001	3	5
OVARY	SACS →	+1.121	+0.132	.009	.002	3	5
BREAST	CLIC4 →	+1.639	+0.237	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032928 vs C19orf48 — BREAST

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