Positive regulation of activin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of activin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATAD2_S342, TEX10, and HEATR1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of activin receptor signaling pathway activity versus ATAD2_S342 in LUAD (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ATAD2_S342 →	+1.099	+0.049	<.001	<.001	3	7
LSCC	TEX10 →	+0.430	+0.072	<.001	<.001	3	7
LSCC	HEATR1 →	+0.533	+0.087	<.001	<.001	3	7
HNSC	NOL10 →	+0.355	+0.074	<.001	<.001	3	7
LSCC	RFC3 →	+0.423	+0.069	<.001	<.001	3	6
LSCC	RIF1_S782 →	+0.914	+0.068	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032927 vs ATAD2_S342 — LUAD

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