Activin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Activin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LGALS1_S30, LOXL2, and ECM2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activin receptor signaling pathway activity versus LGALS1_S30 in LSCC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LGALS1_S30 →	+1.162	+0.078	<.001	<.001	3	8
BRCA	LOXL2 →	+0.712	+0.039	<.001	<.001	3	8
BRCA	ECM2 →	+1.027	+0.035	<.001	<.001	3	8
BRCA	THBS1 →	+0.860	+0.030	<.001	<.001	3	7
LSCC	ACTN1 →	+0.477	+0.082	<.001	<.001	3	7
OV	C1R →	+0.608	+0.043	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032924 vs LGALS1_S30 — LSCC

Explore this scatter interactively →