Activin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Activin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LUCAT1, ANXA2, and APOC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activin receptor signaling pathway activity versus LUCAT1 in LUAD (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LUCAT1 →	-0.871	-0.259	.007	<.001	3	4
GBM	ANXA2 →	-0.653	-0.273	.001	.001	3	4
LSCC	APOC1 →	-0.680	-0.187	.002	.002	3	3
LSCC	FST →	+1.527	+0.240	.001	.005	3	3
HNSC	CARD18 →	+0.586	+0.247	.009	.004	3	3
HNSC	NDUFA3P4 →	-0.244	-0.240	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032924 vs LUCAT1 — LUAD

Explore this scatter interactively →