Activin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Activin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUP214_S657, DCAF1_S979, and LMTK2_S630, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activin receptor signaling pathway activity versus NUP214_S657 in OV (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NUP214_S657 →	-0.616	-0.282	.001	.001	3	4
LSCC	DCAF1_S979 →	-0.717	-0.328	<.001	<.001	3	3
OV	LMTK2_S630 →	-1.997	-0.591	<.001	<.001	3	3
OV	SRRM2_S2382 →	-0.631	-0.260	.001	.007	2	4
GBM	ERBB2_T701 →	-0.576	-0.529	<.001	<.001	3	3
HNSC	FAF1_S320 →	-0.449	-0.388	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032924 vs NUP214_S657 — OV

Explore this scatter interactively →