Activin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Activin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP7, NOL4L, and PPIAL4A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IGFBP7 grouped by Activin receptor signaling pathway-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IGFBP7 →	-3.075	-1.017	.003	<.001	3	4
KIDNEY	NOL4L →	+0.924	+1.030	.009	.008	2	5
SKIN	PPIAL4A →	-0.055	-0.930	<.001	<.001	3	4
LARGE_INTESTINE	LPCAT3 →	+0.929	+0.787	.002	.002	3	3
LARGE_INTESTINE	RPS3 →	+0.424	+0.723	.001	<.001	3	3
LARGE_INTESTINE	RPS23 →	+0.515	+0.716	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGFBP7 by Activin receptor signaling pathway activity — OVARY

Explore this box plot interactively →