Activin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Activin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBR1, ACVR1, and CRIM1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activin receptor signaling pathway activity versus TGFBR1 in LIVER (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TGFBR1 →	+1.760	+0.145	.002	<.001	3	13
BLOOD_Myeloma	ACVR1 →	+1.438	+0.076	.003	.003	3	10
BLOOD_Leukemia	CRIM1 →	+2.037	+0.072	<.001	<.001	3	9
SOFT_TISSUE	NUAK1 →	+1.946	+0.102	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	ITGA5 →	+2.431	+0.139	<.001	<.001	3	8
SOFT_TISSUE	TGFBR2 →	+2.939	+0.108	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032924 vs TGFBR1 — LIVER

Explore this scatter interactively →