Activin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Activin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALR, H3C15, and TARBP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activin receptor signaling pathway activity versus CALR in BREAST (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CALR →	-1.290	-1.847	.009	<.001	3	3
BREAST	H3C15 →	+1.333	+1.982	.006	<.001	3	3
LARGE_INTESTINE	TARBP2 →	+0.458	+0.817	.004	.009	3	3
BREAST	PRKCSH →	-0.955	-1.937	.001	<.001	3	2
BREAST	STARD3 →	+3.465	+1.927	.009	<.001	3	2
BREAST	ARHGAP18 →	-2.483	-1.795	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032924 vs CALR — BREAST

Explore this scatter interactively →