Circadian regulation of gene expression

Across TCGA patient cohorts, RNA activity of the Circadian regulation of gene expression pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX21_S89, CSRP1, and SERPINF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Circadian regulation of gene expression activity versus DDX21_S89 in LSCC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DDX21_S89 →	-0.569	-0.038	.002	.001	3	8
LUAD	CSRP1 →	+0.339	+0.030	.002	.002	3	7
OV	SERPINF1 →	+0.700	+0.048	.002	.004	3	6
BRCA	COL3A1 →	+0.632	+0.038	<.001	<.001	3	6
OV	EZH2_T367 →	-1.415	-0.061	<.001	<.001	3	6
BRCA	PCOLCE →	+0.746	+0.036	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032922 vs DDX21_S89 — LSCC

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