Circadian regulation of gene expression

Across TCGA patient cohorts, RNA activity of the Circadian regulation of gene expression pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB47, MR1, and C19orf48, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Circadian regulation of gene expression activity versus ZBTB47 in OV (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZBTB47 →	-0.690	-0.662	.001	.003	3	5
BRCA	MR1 →	-0.554	-0.799	.002	.002	3	4
OV	C19orf48 →	+0.697	+0.750	<.001	.001	3	4
LSCC	SNHG17 →	+0.527	+0.198	.001	.005	3	4
LSCC	CDK2 →	+0.456	+0.221	.007	.001	3	4
LSCC	SPPL3 →	+0.438	+0.284	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032922 vs ZBTB47 — OV

Explore this scatter interactively →