Circadian regulation of gene expression

Across TCGA cell cohorts, RNA activity of the Circadian regulation of gene expression pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP7D1, SH3BP2, and ZC3H12A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP7D1 grouped by Circadian regulation of gene expression-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAP7D1 →	+0.752	+0.176	.002	<.001	3	5
KIDNEY	SH3BP2 →	+1.391	+0.174	.002	.007	2	6
OESOPHAGUS	ZC3H12A →	+1.158	+0.179	.001	<.001	3	5
BLOOD_Leukemia	GGT1 →	+2.600	+0.278	.001	.007	3	4
BLOOD_Leukemia	ARID3A →	+1.680	+0.306	<.001	.002	3	4
BLOOD_Leukemia	FOXO1 →	-1.849	-0.285	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP7D1 by Circadian regulation of gene expression activity — BREAST

Explore this box plot interactively →