Regulation of transforming growth factor beta1 production

Across TCGA patient cohorts, RNA activity of the Regulation of transforming growth factor beta1 production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP1, SYNPO_S758, and RNGTT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transforming growth factor beta1 production activity versus TOP1 in GBM (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TOP1 →	-0.242	-0.077	.002	.003	3	6
PDAC	SYNPO_S758 →	+0.663	+0.067	<.001	<.001	3	5
LSCC	RNGTT →	-0.210	-0.045	.001	<.001	3	5
UCEC	RRP9 →	-0.223	-0.054	.004	.005	3	5
LSCC	ATAD2_S327 →	-0.992	-0.063	<.001	<.001	3	5
LSCC	BAZ1B_S349 →	-0.828	-0.051	.002	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032908 vs TOP1 — GBM

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