Regulation of transforming growth factor beta1 production

Across TCGA patient cohorts, RNA activity of the Regulation of transforming growth factor beta1 production pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLKL, GPBAR1, and PLEK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transforming growth factor beta1 production activity versus MLKL in GBM (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MLKL →	+0.671	+0.160	<.001	<.001	3	4
OV	GPBAR1 →	+0.210	+0.083	.008	.004	3	4
PDAC	PLEK2 →	+0.481	+0.610	.003	.007	3	3
GBM	HSDL1 →	-0.263	-0.128	.007	.007	3	3
GBM	MYEF2 →	-0.524	-0.161	<.001	<.001	3	3
OV	TCIRG1 →	+0.720	+0.119	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032908 vs MLKL — GBM

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