Regulation of transforming growth factor beta1 production

Across TCGA cell cohorts, RNA activity of the Regulation of transforming growth factor beta1 production pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP3, SWT1, and CPNE5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNFAIP3 grouped by Regulation of transforming growth factor beta1 production-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TNFAIP3 →	+1.574	+0.759	.006	.002	3	4
URINARY_TRACT	SWT1 →	+0.700	+1.688	<.001	<.001	3	3
URINARY_TRACT	CPNE5 →	+0.366	+1.743	.003	<.001	3	3
SOFT_TISSUE	PCGF1 →	+0.950	+1.520	.001	.002	3	3
KIDNEY	CD177 →	+0.889	+1.102	.003	.003	3	3
BREAST	RAD51C →	-1.184	-0.751	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNFAIP3 by Regulation of transforming growth factor beta1 production activity — BREAST

Explore this box plot interactively →