Negative regulation of organic acid transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of organic acid transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGAP3, KIF13B, and NT5C1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PGAP3 grouped by Negative regulation of organic acid transport-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PGAP3 →	+2.378	+1.295	.008	.005	2	7
LUNG_NSCLC_LUAD	KIF13B →	+0.941	+0.834	.007	.002	3	5
KIDNEY	NT5C1B →	+0.241	+0.996	<.001	.002	3	5
LARGE_INTESTINE	PTPN18 →	+0.816	+1.244	.003	<.001	3	5
LUNG_NSCLC_LUAD	RFX1 →	+0.351	+0.773	.005	.003	2	5
LUNG_NSCLC_LUAD	MKRN1 →	+0.832	+0.975	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PGAP3 by Negative regulation of organic acid transport activity — OESOPHAGUS

Explore this box plot interactively →