Negative regulation of organic acid transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of organic acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRAS, SCAMP5, and CNNM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of organic acid transport activity versus RRAS in LIVER (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RRAS →	+2.297	+0.418	.006	<.001	3	5
STOMACH	SCAMP5 →	-2.433	-0.172	.001	.007	3	5
PANCREAS	CNNM2 →	-0.819	-0.259	.005	.004	3	5
LARGE_INTESTINE	GP1BA →	-0.867	-0.284	.007	.009	2	6
LARGE_INTESTINE	CPT1B →	-1.225	-0.274	.002	.001	3	5
BLOOD_Myeloma	ZNF500 →	-0.472	-0.321	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032891 vs RRAS — LIVER

Explore this scatter interactively →