Regulation of organic acid transport

Across TCGA patient cohorts, RNA activity of the Regulation of organic acid transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, MRPL11, and TRMT112, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of organic acid transport activity versus IRS2 in GBM (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IRS2 →	+0.939	+0.251	<.001	<.001	3	7
HNSC	MRPL11 →	-0.649	-0.163	.002	.003	3	5
COAD	TRMT112 →	-0.512	-0.252	.002	<.001	3	5
UCEC	ZWINT →	-0.792	-0.183	.001	.001	3	5
UCEC	KNL1 →	-0.626	-0.187	<.001	<.001	3	5
BRCA	PLK4 →	-0.699	-0.695	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032890 vs IRS2 — GBM

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