Regulation of organic acid transport

Across TCGA cell cohorts, RNA activity of the Regulation of organic acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMELESS, DNAJC3, and WNT3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TIMELESS grouped by Regulation of organic acid transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TIMELESS →	+0.672	+0.872	<.001	.001	3	6
BLOOD_Leukemia	DNAJC3 →	-0.896	-0.841	<.001	<.001	3	4
CNS	WNT3 →	+0.944	+0.907	<.001	.004	3	3
CNS	FANCC →	+0.486	+1.036	.006	<.001	2	4
LUNG_NSCLC_LUAD	GTPBP4 →	-0.823	-0.860	<.001	<.001	3	3
OESOPHAGUS	GXYLT1 →	+0.888	+1.244	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TIMELESS by Regulation of organic acid transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →