Regulation of microtubule-based process

Across TCGA cell cohorts, RNA activity of the Regulation of microtubule-based process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM117, ISYNA1, and LARS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule-based process activity versus TMEM117 in OVARY (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TMEM117 →	-1.327	-0.209	<.001	.002	3	6
SOFT_TISSUE	ISYNA1 →	-3.771	-0.133	<.001	.003	3	5
BLOOD_Leukemia	LARS1 →	-0.363	-0.077	.002	.001	3	5
OVARY	KLHL13 →	-2.009	-0.160	.005	.003	3	5
URINARY_TRACT	FCMR →	+1.484	+0.200	.009	.005	3	5
URINARY_TRACT	ANXA5 →	+1.904	+0.229	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032886 vs TMEM117 — OVARY

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