Regulation of polysaccharide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of polysaccharide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDAH2, ENPP1, and IRS1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of polysaccharide biosynthetic process activity versus DDAH2 in COAD (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DDAH2 →	+0.419	+0.039	<.001	<.001	3	8
COAD	ENPP1 →	+0.730	+0.047	.001	<.001	3	7
BRCA	IRS1 →	+0.542	+0.052	<.001	<.001	3	6
COAD	JPT1 →	-0.632	-0.046	<.001	<.001	3	6
OV	LAMA4 →	+0.495	+0.053	<.001	<.001	3	6
UCEC	ARHGEF7_S25 →	+0.854	+0.063	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032885 vs DDAH2 — COAD

Explore this scatter interactively →