Regulation of polysaccharide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of polysaccharide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC32, LAMA2, and CNN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of polysaccharide biosynthetic process activity versus LRRC32 in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LRRC32 →	+0.733	+0.577	<.001	.001	3	7
UCEC	LAMA2 →	+1.301	+0.604	<.001	<.001	3	7
UCEC	CNN1 →	+2.483	+0.508	<.001	.001	2	7
UCEC	JAM3 →	+0.909	+0.495	<.001	.001	3	6
PDAC	TPM2 →	+0.334	+0.384	.007	.008	3	6
UCEC	CNTN4 →	+0.727	+0.411	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032885 vs LRRC32 — BRCA

Explore this scatter interactively →