Regulation of polysaccharide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of polysaccharide biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1CB, CLTC, and RBM41, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1CB grouped by Regulation of polysaccharide biosynthetic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PPP1CB →	-0.491	-0.442	<.001	.008	3	9
OVARY	CLTC →	-0.539	-0.286	<.001	.001	3	6
BLOOD_Lymphoma	RBM41 →	+0.367	+0.369	.005	<.001	3	4
OVARY	CD72 →	+0.283	+0.272	.001	.006	3	4
OVARY	PCBP2 →	+0.205	+0.325	<.001	<.001	3	4
SOFT_TISSUE	IGF2 →	-0.407	-0.355	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1CB by Regulation of polysaccharide biosynthetic process activity — CNS

Explore this box plot interactively →