Regulation of polysaccharide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of polysaccharide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARS2, SEMA7A, and C12orf73, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of polysaccharide biosynthetic process activity versus MARS2 in LIVER (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MARS2 →	-1.163	-0.412	<.001	.002	3	6
BONE	SEMA7A →	+4.335	+0.299	<.001	.003	3	6
BONE	C12orf73 →	-1.430	-0.237	<.001	.005	3	6
BONE	CCDC80 →	+4.999	+0.339	.001	.004	3	6
BLOOD_Lymphoma	TNIP1 →	+1.240	+0.201	.002	.001	3	5
UPPER_AERODIGESTIVE_TRACT	C1QBP →	-1.365	-0.243	.002	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032885 vs MARS2 — LIVER

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