Regulation of polysaccharide metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of polysaccharide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPN2, GDI1, and LAMA4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of polysaccharide metabolic process activity versus PTPN2 in COAD (Pearson r = -0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PTPN2 →	-0.279	-0.039	<.001	<.001	3	6
BRCA	GDI1 →	+0.275	+0.036	.001	.001	3	6
OV	LAMA4 →	+0.530	+0.040	<.001	<.001	3	6
COAD	RPL30_S10 →	-0.447	-0.047	<.001	<.001	3	5
LSCC	SDC2 →	+0.555	+0.039	.001	<.001	3	5
COAD	SMOC2 →	+0.950	+0.038	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032881 vs PTPN2 — COAD

Explore this scatter interactively →