Regulation of polysaccharide metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of polysaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAM3, IRS2, and AOC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of polysaccharide metabolic process activity versus JAM3 in UCEC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JAM3 →	+0.868	+0.613	<.001	<.001	3	6
LUAD	IRS2 →	+1.544	+1.301	<.001	<.001	3	6
BRCA	AOC3 →	+0.973	+0.584	<.001	<.001	3	5
HNSC	RBMS3 →	+0.627	+0.333	.001	.008	3	5
UCEC	LMOD1 →	+1.927	+0.606	<.001	<.001	3	5
BRCA	FAM180A →	+0.710	+0.756	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032881 vs JAM3 — UCEC

Explore this scatter interactively →