Regulation of polysaccharide metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of polysaccharide metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1CB, IGF2, and SLK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1CB grouped by Regulation of polysaccharide metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PPP1CB →	-0.429	-0.338	.005	.004	3	8
SOFT_TISSUE	IGF2 →	-0.383	-0.367	<.001	<.001	3	6
SOFT_TISSUE	SLK →	-0.161	-0.273	<.001	.001	3	5
LIVER	TMEM97 →	+0.215	+0.315	<.001	.001	3	4
BONE	PHKG2 →	-0.354	-0.389	.006	.003	3	4
KIDNEY	DGKH →	+0.260	+0.347	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1CB by Regulation of polysaccharide metabolic process activity — KIDNEY

Explore this box plot interactively →