Regulation of polysaccharide metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of polysaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMSS1, MED1, and TAOK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CMSS1 grouped by Regulation of polysaccharide metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CMSS1 →	-0.893	-0.242	.007	.001	2	6
LIVER	MED1 →	-0.545	-0.262	.002	.003	3	4
LIVER	TAOK1 →	-0.759	-0.261	<.001	.004	3	4
OVARY	ABCE1 →	-0.540	-0.592	.003	.009	3	4
OVARY	PRMT3 →	-0.650	-0.584	.006	.008	2	5
OVARY	ZNF37A →	-0.618	-0.454	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CMSS1 by Regulation of polysaccharide metabolic process activity — PANCREAS

Explore this box plot interactively →