Regulation of polysaccharide metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of polysaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLDB2, PBXIP1, and TIMM13, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of polysaccharide metabolic process activity versus PHLDB2 in STOMACH (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PHLDB2 →	+2.822	+0.256	.002	.002	3	5
OVARY	PBXIP1 →	+1.305	+0.235	<.001	.003	3	5
KIDNEY	TIMM13 →	-0.956	-0.250	.001	.003	3	5
BREAST	RNF185 →	-0.622	-0.194	.006	.003	2	6
BONE	SEMA7A →	+3.199	+0.261	.005	.003	3	4
BLOOD_Leukemia	ETFA →	-0.415	-0.167	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032881 vs PHLDB2 — STOMACH

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