Cellular response to insulin stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to insulin stimulus pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EML6, CYB5D1, and WDR43, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EML6 grouped by Cellular response to insulin stimulus-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	EML6 →	-1.084	-0.645	.001	.005	3	4
SOFT_TISSUE	CYB5D1 →	-1.270	-1.081	<.001	.005	3	4
LARGE_INTESTINE	WDR43 →	-0.410	-0.217	.009	.004	3	4
BLOOD_Leukemia	MDH1 →	-0.878	-0.225	<.001	.001	3	3
URINARY_TRACT	MELTF →	+2.811	+0.240	<.001	<.001	3	3
URINARY_TRACT	COPZ2 →	+3.500	+0.240	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EML6 by Cellular response to insulin stimulus activity — CNS

Explore this box plot interactively →