Response to insulin

Across TCGA patient cohorts, RNA activity of the Response to insulin pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, RIF1_S782, and SEPTIN4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to insulin activity versus SMC2 in LSCC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC2 →	-0.466	-0.025	<.001	<.001	3	8
GBM	RIF1_S782 →	-0.655	-0.029	<.001	<.001	3	8
LUAD	SEPTIN4 →	+0.447	+0.027	<.001	<.001	3	8
LUAD	SEPTIN4_S432 →	+0.593	+0.027	<.001	<.001	3	8
LSCC	SPTBN1_S257 →	+0.605	+0.037	.001	<.001	3	8
OV	TNS2_S102 →	+0.681	+0.031	.005	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032868 vs SMC2 — LSCC

Explore this scatter interactively →