Response to insulin

Across TCGA cell cohorts, RNA activity of the Response to insulin pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHRS3, CEACAM19, and ARHGEF5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHRS3 grouped by Response to insulin-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DHRS3 →	+2.648	+0.569	.001	.009	3	4
LUNG_SCLC	CEACAM19 →	+1.288	+0.134	.004	.001	3	3
LUNG_SCLC	ARHGEF5 →	+2.635	+0.201	<.001	<.001	3	3
SKIN	FOXP3 →	-0.168	-0.385	.006	.009	3	3
URINARY_TRACT	BHLHE40 →	+1.662	+0.343	.002	.001	3	3
BONE	KIAA0513 →	+1.085	+0.208	.006	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHRS3 by Response to insulin activity — SKIN

Explore this box plot interactively →