Response to insulin

Across TCGA cell cohorts, RNA activity of the Response to insulin pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC22C, PPDPF, and POLR2D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to insulin activity versus SEC22C in STOMACH (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SEC22C →	-0.863	-0.150	.003	<.001	3	5
BONE	PPDPF →	+0.984	+0.147	.001	.009	3	5
STOMACH	POLR2D →	-0.550	-0.128	.001	.005	3	5
BONE	CACHD1 →	-2.248	-0.205	.002	.005	3	4
OESOPHAGUS	C12orf57 →	-1.120	-0.162	<.001	<.001	3	4
BLOOD_Leukemia	GPR63 →	-0.934	-0.140	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032868 vs SEC22C — STOMACH

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