Glomerular basement membrane development

Across TCGA patient cohorts, RNA activity of the Glomerular basement membrane development pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INHBA, SULF1, and ITGA11, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular basement membrane development activity versus INHBA in CHOL (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	INHBA →	+2.122	+0.089	.001	<.001	3	31
TGCT	SULF1 →	+2.965	+0.158	<.001	<.001	3	31
OV	ITGA11 →	+1.928	+0.113	<.001	<.001	3	31
DLBC	MYOF →	+1.857	+0.073	<.001	<.001	2	32
MESO	NID2 →	+1.914	+0.093	<.001	<.001	3	31
THYM	NRP1 →	+1.453	+0.061	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032836 vs INHBA — CHOL

Explore this scatter interactively →