Glomerular basement membrane development

Across TCGA cell cohorts, RNA activity of the Glomerular basement membrane development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AURKC, GATAD2B, and FGF13, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular basement membrane development activity versus AURKC in BREAST (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	AURKC →	+1.600	+1.805	.002	.002	3	3
BREAST	GATAD2B →	-0.879	-1.861	.001	.004	3	3
BREAST	FGF13 →	-2.745	-1.761	.005	.002	3	2
BREAST	MSI1 →	-0.899	-1.805	.009	.002	3	2
BREAST	TARS2 →	-1.370	-1.705	.003	<.001	3	2
BREAST	ILF2 →	-1.021	-1.705	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032836 vs AURKC — BREAST

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