"Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation"

Across TCGA patient cohorts, RNA activity of the "Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ISG20, WARS1, and CD48, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" activity versus ISG20 in CCRCC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ISG20 →	-0.536	-0.058	<.001	<.001	3	7
CCRCC	WARS1 →	-0.471	-0.066	<.001	<.001	3	6
OV	CD48 →	-0.859	-0.070	<.001	<.001	3	6
OV	LCP2 →	-0.456	-0.070	<.001	<.001	3	6
OV	RAC2 →	-0.619	-0.069	<.001	<.001	3	6
CCRCC	CD4 →	-0.328	-0.056	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032829 vs ISG20 — CCRCC

Explore this scatter interactively →