"Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation"

Across TCGA patient cohorts, RNA activity of the "Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIRC3, STX11, and HLA-DRA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" activity versus BIRC3 in LSCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BIRC3 →	+0.864	+0.124	.002	.005	3	7
GBM	STX11 →	+0.477	+0.099	<.001	<.001	3	6
COAD	HLA-DRA →	+1.107	+0.078	<.001	<.001	3	6
COAD	SNRNP70 →	-0.478	-0.051	<.001	.008	3	6
GBM	BTK →	+0.531	+0.092	<.001	<.001	3	6
CCRCC	CD80 →	+0.519	+0.154	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032829 vs BIRC3 — LSCC

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