"Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation"

Across TCGA patient cohorts, RNA activity of the "Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LGALS9, STK10, and CCDC88B_S597, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" activity versus LGALS9 in CCRCC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LGALS9 →	+0.551	+0.216	<.001	<.001	3	8
HNSC	STK10 →	+0.350	+0.138	<.001	<.001	3	5
CCRCC	CCDC88B_S597 →	+0.682	+0.205	<.001	<.001	3	5
COAD	HLA-DRB1 →	+0.744	+0.083	<.001	<.001	3	5
LSCC	ARHGAP15_S43 →	+0.566	+0.116	<.001	<.001	3	5
CCRCC	ALOX5 →	+0.660	+0.187	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032829 vs LGALS9 — CCRCC

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