Positive regulation of natural killer cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of natural killer cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP6, SPON1, and ABCA9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of natural killer cell differentiation activity versus MAP6 in UCEC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP6 →	+0.563	+0.190	.007	.008	3	4
UCEC	SPON1 →	+1.106	+0.145	.004	.009	3	4
HNSC	ABCA9 →	+0.707	+0.089	<.001	<.001	3	4
HNSC	HSPB7 →	+1.505	+0.098	.001	.002	3	4
HNSC	ACTA2-AS1 →	+0.464	+0.091	<.001	<.001	3	4
UCEC	SRPX →	+0.818	+0.132	.005	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032825 vs MAP6 — UCEC

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