Positive regulation of natural killer cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of natural killer cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAX, TEAD1, and MYBL2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAX grouped by Positive regulation of natural killer cell differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MAX →	-0.562	-0.431	<.001	<.001	3	8
BONE	TEAD1 →	+0.311	+0.312	.007	.001	3	8
SOFT_TISSUE	MYBL2 →	-0.419	-0.211	<.001	.001	3	7
BONE	DUSP13 →	-0.366	-0.316	<.001	.001	3	6
CNS	PRKCZ →	-0.235	-0.232	.002	<.001	3	6
LUNG_NSCLC_LUAD	DOP1B →	-0.239	-0.259	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAX by Positive regulation of natural killer cell differentiation activity — BONE

Explore this box plot interactively →