Positive regulation of natural killer cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of natural killer cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAS6, AXL, and MARCHF4, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of natural killer cell differentiation activity versus GAS6 in LUNG_NSCLC_LUSC (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GAS6 →	+4.531	+0.587	<.001	.001	3	18
LIVER	AXL →	+5.313	+1.076	<.001	.002	3	13
LIVER	MARCHF4 →	+2.124	+0.750	.001	.002	3	13
BONE	NT5E →	+4.471	+0.320	<.001	<.001	3	12
LIVER	FOSL1 →	+4.691	+0.963	<.001	.004	3	12
BONE	PARP3 →	+1.294	+0.324	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032825 vs GAS6 — LUNG_NSCLC_LUSC

Explore this scatter interactively →